Arsenal will be looking to bounce back from their 1-0 defeat to Sheffield United on Monday night, while Manchester United will want to build from their impressive performance against Liverpool.
The Merseysiders will want to maintain their undefeated start to the season by piling more misery on Tottenham in the Premier League while Pochettino will want his side to regain momentum following their Champions league success against Red Star Belgrade on Tuesday night.
Super Sunday: How you can listen
Liverpool vs Tottenham is the only televised game to feature the big six on Sunday and is available on Sky Sports from 4pm.
You can listen to regular updates and expert opinions on talkSPORT throughout the day while Simon Jordan will recap all the weekend’s Premier League action on Final Word from 5pm.
Arsenal vs Crystal Palace – Sunday October 27, 16:30
The two London clubs sit one place apart in the Premier League with Arsenal holding onto fifth having picked up one more point than Crystal Palace.
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Both teams have started the season in similar fashion, both have four wins from the first nine games as well as two wins in their last five.
They also both lost in their most recent outing, with Palace suffering a 2-0 defeat at home to Manchester City while Arsenal lost 1-0 away to Sheffield United.