Monday’s match is a repeat of the infamous ‘Battle of Old Trafford’ of 2003, although there will be precious little at stake other than pride in this edition of the historic meeting.
That fixture has gone down in history as one of the most ferocious matches the Premier League has ever seen.
There were eight bookings dished out by the referee and Gunners players furiously confronting United striker Ruud van Nistelrooy at the full-time whistle after he missed a late penalty and, they felt, had earlier got captain Patrick Vieira sent off.
It ended in a 0-0 draw, a crucial result for Arsenal who were later crowned league champions with an undefeated record – ‘The Invincibles’ were born.
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However, both sides will go into this game in very different circumstances.
Arsenal and United are no longer fighting at the very top of English football, and haven’t been those teams for quite some time.
Instead, they appear to have become mere spectators as title challengers Manchester City and Liverpool gallop into the distance, with managers Unai Emery and Ole Gunnar Solksjaer both feeling the strain in their respective dugouts.