talkSPORT has more games than ever before this season and will be starting things off with the Championship clash at Luton.
The Hatters won League One last season to gain promotion, while Boro just missed out on the play-off places.
Now they are set to go head-to-head in the opening fixture of the 2019/20 EFL season.
At Kenilworth Road, the last league meeting between the two sides ended in a 5-1 victory for the Hatters in October 1994 under manager David Pleat, while Luton last started a league season at Kenilworth Road in the 2017/18 season, thrashing Yeovil 8-2.
In doing so, they became the first team to score eight goals in an opening day Football League match since Wolves in August 1962.
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Luton vs Middlesbrough: Confirmed Teams
Luton: Sluga, Cranie, Bradley, Pearson, Potts, Tunnicliffe, Shinnie, Mpanzu, Lee, McManaman, Collins.
Subs: Galloway, Butterfield, Berry, Cornick, Moncur, Jones, Shea.
Middlesbrough: Randolph, Howson, Ayala, Shotton, Coulson, Wing, Clayton, McNair, Fletcher, Assombalonga, Johnson.
Subs: Tavernier, Browne, Gestede, Saville, Wood-Gordon, Bola, Pears.