The two former European Championship winners have been drawn together in Group C as they look to qualify for Euro 2020 next summer.
Northern Ireland currently lead the group with four wins from four but Germany are unbeaten in their three games while the Dutch have only played twice so far.
They will meet at the Volksparkstadion in Hamburg.
Euro 2020 explained: How it works, stadiums and dates as tournament celebrates 60th anniversary
Three-time champions Germany last won the Euros in 1996 when they beat the Czech Republic at Wembley while Holland won it in 1988.
Both will be looking for glory next summer but will first have to negotiate their tricky qualifying group.
Germany are without a host of key players as they bid to knock Northern Ireland off top spot on goal difference.
Leroy Sane, Julian Draxler, Thilo Kehrer and Antonio Rudiger have all been ruled out through injury and Bayern Munich’s Leon Goretzka remains sidelined after aggravating a heavy bruise while training with Joachim Low’s squad this week.
Holland, who failed to qualify for both Euro 2016 and the 2018 World Cup finals, are third in Group C, six points behind Northern Ireland and Germany, but with games in hand.
The Dutch beat England 3-1 in the Nations League semi-finals in June before losing to Portugal in the final, but a second Euro qualifying defeat would leave them with plenty of ground to make up.
Ronald Koeman is without Donny van de Beek, Steven Bergwijn and Stefan De Vrij due to injury.
Click Here: cheap true religion jeans