The goalkeeper, who is currently playing on loan at Sheffield United from Manchester United, will link up with his new international team-mates at St George’s Park on Wednesday ahead of their Euro 2020 qualifiers at Czech Republic and Bulgaria.
The FA revealed Heaton had returned to Aston Villa for ‘further assessment’ on an unspecified injury sustained during the 5-1 win over Norwich last weekend.
Heaton becomes the second player to withdraw from the Three Lions’ squad, with Everton man Fabian Delph also picking up an injury.
Henderson has represented England from Under-16 through to the Under-21s.
He said on Twitter: “This is what dreams are made of… it’s a dream come true to receive my first @England senior call up!!”
The 22-year-old is in his second season on loan with the Blades, having played a key role in their promotion to the Premier League last season.
He has yet to make a senior appearance for his parent club and has previously spent time on loan at Stockport, Grimsby and Shrewsbury.
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Henderson had found himself in the spotlight following an error which gifted Liverpool the winning goal in their recent 1-0 victory at Bramall Lane.
However, Henderson dusted himself off and kept a clean sheet in the Blades’ next Premier League encounter, which saw them play out a goalless draw at Watford.
And Sheffield United boss Chris Wilder always felt the young goalkeeper could quickly put it behind him.
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