The Red Devils have been drawn in Group L of Europe’s secondary competition and will also face AZ Alkmaar and Partizan Belgrade over the coming weeks.
United claimed glory in the tournament in 2017 and are among the firm favourites to do so again this term.
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Manchester United vs Astana: Date and kick-off time
The opening game in Group L will be held on Thursday, September 19 and will kick-off at 8pm UK time.
This will be the first competitive meeting between the two sides.