There have been memorable games between the two clubs, with United narrowly getting the better of the Saints in the EFL Cup final in 2017.
Southampton had come back from two goals down to stun the Red Devils, but Zlatan Ibrahimovic’s 87th-minute header won it for Jose Mourinho’s men.
It was more silverware to put in the club’s jam-packed trophy cabinet after years of success during Sir Alex Ferguson’s reign.
Below, talkSPORT.com explains how Southampton played a pivotal role in Ferguson’s arrival at Old Trafford.
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