The Argentine striker was preferred to Gabriel Jesus to start the clash and he rewarded his manager with an astute finish to put the hosts 2-1 ahead.
However, the pair exchanged angry words on the sidelines when Aguero was substituted for Jesus midway through the second half, shortly after Lucas Moura had levelled things up for Spurs.
The incident dragged on for an awkward amount of time, with Mikel Arteta playing the role of peacekeeper.
The pair later embraced on the pitch after the match ended 2-2, and Guardiola explained what prompted the bust-up.
He said: “Aguero believed I was upset with him for the goal we conceded. The goal we conceded was a corner.
“I wanted one on one movement. He thought I was upset with him.
“I am sometimes exaggerated on the touchline but few times am I upset with the players.
“I was a football player, I know what it is like to be in there. Emotion is part of our game. We talked after and during. He’s a guy I love a lot.”
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