The 24-year-old midfielder, who has been heavily linked with a move to Old Trafford in recent days, also appeared to wave goodbye to the crowd after the game.
Fernandes has become one of the most coveted players in the world after scoring a record-breaking 31 goals in the Portuguese top-flight last season.
And while the Red Devils are yet to agree a fee with Sporting, the Portugal midfielder’s tears on Sunday night suggest he may have played his final game for the Primeira Liga club.
Fernandes grew increasingly emotional after he was replaced by Daniel Braganca in the 89th minute of Sporting’s 2-1 defeat to Valencia.